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Article

CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves' disease and modulates clinical phenotype of disease.

Endocrine - 1 Jan 2017

Pawlak-Adamska Edyta, Frydecka Irena, Bolanowski Marek, Tomkiewicz Anna, Jonkisz Anna, Karabon Lidia, Partyka Anna, Nowak Oskar, Szalinski Marek, Daroszewski Jacek

Abstract excerpt

Graves' disease, an autoimmune disease with heterogeneous symptoms including Graves' orbitopathy, has a combined genetic/environmental background, where variations within CD28/CTLA-4/ICOS genes are considered as disease markers.Association of CD28c.17+3T>C(rs3116496), CTLA-4g.319C>T(rs5742909), CTLA-4c.49A>G(rs231775), CTLA-4g.*642AT(8_33), CT60(rs3087243), Jo31(), ICOSc.1554+4GT(8_15) polymorphisms...

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Share to Aged, 80 and over
Share to CD28 Antigens
Share to CTLA-4 Antigen
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Share to Graves Ophthalmopathy
Share to Haplotypes
Share to Inducible T-Cell Co-Stimulator Protein
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Source

Open in PubMed Open full text

Identifiers

PMID: 27638540
DOI: 10.1007/s12020-016-1096-1
PMCID: PMC5225215

Genes

ICOS

Variants

rs5742909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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