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Article

EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.

Cancer science - 1 Dec 2016

Endo Akifumi, Tomizawa Daisuke, Aoki Yuki, Morio Tomohiro, Mizutani Shuki, Takagi Masatoshi

Abstract excerpt

The Ewing sarcoma breakpoint region 1 (EWSR1) gene is known to fuse with various partner genes to promote the development of the Ewing sarcoma family of tumors and other sarcomas. In contrast, the association of EWSR1 chimeric fusion genes with leukemia has rarely been reported. We identified a novel EWSR1-associated chimeric fusion gene in a patient with acute myeloid leukemia harboring 46, XY, t (11; 22) (p13;...

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Source

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Identifiers

PMID: 27627705
DOI: 10.1111/cas.13080
PMCID: PMC5198945

Genes

EWSR1
ELF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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