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Article

EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing's Sarcoma

28 Aug 2008

Abstract excerpt

Although p53 is the most frequently mutated gene in cancer, half of human tumors retain wild-type p53, whereby it is unknown whether normal p53 function is compromised by other cancer-associated alterations. One example is Ewing's sarcoma family tumors (ESFT), where 90% express wild-type p53. ESFT are characterized by EWS-FLI1 oncogene fusions. Studying 6 ESFT cell lines, silencing of EWS-FLI1 in a wild-type p53...

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PMID: 18757425
DOI: 10.1158/0008-5472.can-07-6145

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