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Successful application of endoscopic ultrasound-guided fine needle biopsy to establish pancreatic patient-derived tumor xenografts: a pilot study.

Endoscopy - 1 Nov 2016

Hermans Els, Van der Merwe Schalk W, Depreeuw Jeroen, Dekervel Jeroen, Radaelli Enrico, Roskams Tania, van Pelt Jos Jos, Topal Baki, Verslype Chris, Prenen Hans, Van Steenbergen Werner, Nevens Frederik, Lambrechts Diether, Amant Frédéric

Abstract excerpt

Background and study aim: Typically, pancreatic patient-derived tumor xenografts (PDXs) are established by transplanting large tumor biopsies obtained through invasive surgery approaches into immunocompromised mice. We aimed to develop pancreatic PDXs by transplanting tumor tissue acquired by endoscopic ultrasound (EUS)-guided fine needle biopsies (FNB), assess take rates compared to surgery-derived PDXs, and...

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Identifiers

PMID: 27626319
DOI: 10.1055/s-0042-113597

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