Article
Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis.
PloS one - 1 Jan 2016
Kaisaki Pamela J, Cutts Anthony, Popitsch Niko, Camps Carme, Pentony Melissa M, Wilson Gareth, Page Suzanne, Kaur Kulvinder, Vavoulis Dimitris, Henderson Shirley, Gupta Avinash, Middleton Mark R, Karydis Ioannis, Talbot Denis C, Schuh Anna, Taylor Jenny C
Abstract excerpt
Use of circulating tumour DNA (ctDNA) as a liquid biopsy has been proposed for potential identification and monitoring of solid tumours. We investigate a next-generation sequencing approach for mutation detection in ctDNA in two related studies using a targeted panel. The first study was retrospective, using blood samples taken from melanoma patients at diverse timepoints before or after treatment, aiming to...
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