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Monitoring Somatic Genetic Alterations in Circulating Cell-Free DNA/RNA of Patients with "Oncogene-Addicted" Advanced Lung Adenocarcinoma: A Real-World Clinical Study.

International journal of molecular sciences - 1 Aug 2022

Lupini Laura, Roncarati Roberta, Belluomini Lorenzo, Lancia Federica, Bassi Cristian, D'Abundo Lucilla, Michilli Angelo, Guerriero Paola, Fasano Alessandra, Tiberi Elisa, Salamone Andrea, Cosi Donato Michele, Saccenti Elena, Tagliatti Valentina, Maestri Iva, Sabbioni Silvia, Volinia Stefano, Gafà Roberta, Lanza Giovanni, Frassoldati Antonio, Negrini Massimo

Abstract excerpt

Liquid biopsy has advantages over tissue biopsy, but also some technical limitations that hinder its wide use in clinical applications. In this study, we aimed to evaluate the usefulness of liquid biopsy for the clinical management of patients with advanced-stage oncogene-addicted non-small-cell lung adenocarcinomas. The investigation was conducted on a series of cases-641 plasma samples from 57...

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Adenocarcinoma
Adenocarcinoma of Lung
Carcinoma, Non-Small-Cell Lung
Cell-Free Nucleic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Circulating Tumor DNA

High-Throughput Nucleotide Sequencing

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Open in PubMed Open full text

Identifiers

PMID: 35955679
DOI: 10.3390/ijms23158546
PMCID: PMC9369384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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