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Article

An APOC3 3'UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site.

Scientific reports - 14 Sept 2016

Hu Sen-Lin, Cui Guang-Lin, Huang Jin, Jiang Jian-Gang, Wang Dao-Wen

Abstract excerpt

Apolipoprotein C-III (APOC3) is a key regulator of plasma triglycerides levels. Increasing evidence has shown that loss-of-function mutations in APOC3 is associated with reduction in plasma triglycerides levels and will confer a benefit in patients at high risk for cardiovascular disease. However, these favorable mutations were extremely distribution discrepant among different ethnics. In this study, the APOC3...

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Source

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Identifiers

PMID: 27624799
DOI: 10.1038/srep32700
PMCID: PMC5021972

Genes

APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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An APOC3 3'UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site.PMID 27624799Read ↗

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.Semantic proximity Read ↗

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter.Semantic proximity Read ↗

APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups.Semantic proximity Read ↗

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.Semantic proximity Read ↗

A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency.Semantic proximity Read ↗

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.Semantic proximity Read ↗

Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysis.Semantic proximity Read ↗

Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population.Semantic proximity Read ↗

[Mutations of APOC3 gene, metabolism of triglycerides and reduction of ischemic cardiovascular events].Semantic proximity Read ↗

Lack of evidence for a liver or intestinal miRNA regulation involved in the hypertriglyceridemic effect of APOC3 3'UTR variant SstI.Semantic proximity Read ↗

Contribution of apolipoprotein C-III gene variants to determination of triglyceride levels and interaction with smoking in middle-aged men.Semantic proximity Read ↗

Loss-of-function mutations in APOC3 and risk of ischemic vascular disease.Semantic proximity Read ↗

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