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Article

Loss-of-function mutations in APOC3 and risk of ischemic vascular disease.

The New England journal of medicine - 3 Jul 2014

Jørgensen Anders Berg, Frikke-Schmidt Ruth, Nordestgaard Børge G, Tybjærg-Hansen Anne

Abstract excerpt

BACKGROUND: High plasma levels of nonfasting triglycerides are associated with an increased risk of ischemic cardiovascular disease. Whether lifelong low levels of nonfasting triglycerides owing to mutations in the gene encoding apolipoprotein C3 (APOC3) are associated with a reduced risk of ischemic cardiovascular disease in the general population is unknown. METHODS: Using data from 75,725 participants in two...

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Identifiers

PMID: 24941082
DOI: 10.1056/NEJMoa1308027

Genes

APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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