An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.

doi:10.1016/j.ajhg.2013.12.001

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.

American journal of human genetics - 2 Jan 2014

Caussy Cyrielle, Charrière Sybil, Marçais Christophe, Di Filippo Mathilde, Sassolas Agnès, Delay Mireille, Euthine Vanessa, Jalabert Audrey, Lefai Etienne, Rome Sophie, Moulin Philippe

Abstract excerpt

APOA5 c.*158C>T (rs2266788), located in the 3' UTR, belongs to APOA5 haplotype 2 (APOA5*2), which is strongly associated with plasma triglyceride levels and modulates the occurrence of both moderate and severe hypertriglyceridemia. Individuals with APOA5*2 display reduced APOA5 expression at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein A-V

Share to Apolipoproteins A

Share to Down-Regulation

Share to HEK293 Cells

Share to Luciferases

Share to MicroRNAs

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 24387992
DOI: 10.1016/j.ajhg.2013.12.001
PMCID: PMC3882731

Genes

APOA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24387992-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site.PMID 24387992Read ↗

Mutations of the apolipoprotein A5 gene with inherited hypertriglyceridaemia: review of the current literature.Semantic proximity Read ↗

Genetic variation in apolipoprotein A-V in hypertriglyceridemia.Semantic proximity Read ↗

A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency.Semantic proximity Read ↗

Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism.Semantic proximity Read ↗

Multiple microRNA regulation of lipoprotein lipase gene abolished by 3'UTR polymorphisms in a triglyceride-lowering haplotype harboring p.Ser474Ter.Semantic proximity Read ↗

Update on APOA5 Genetics: Toward a Better Understanding of Its Physiological Impact.Semantic proximity Read ↗

The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research.Semantic proximity Read ↗

Apolipoprotein A5 and triglyceridemia. Focus on the effects of the common variantsSemantic proximity Read ↗

A promoter variant of the APOA5 gene increases atherogenic LDL levels and arterial stiffness in hypertriglyceridemic patients.Semantic proximity Read ↗

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.Semantic proximity Read ↗

Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice.Semantic proximity Read ↗

Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.