Article
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
The New England journal of medicine - 3 Jul 2014
Crosby Jacy, Peloso Gina M, Auer Paul L, Crosslin David R, Stitziel Nathan O, Lange Leslie A, Lu Yingchang, Tang Zheng-zheng, Zhang He, Hindy George, Masca Nicholas, Stirrups Kathleen, Kanoni Stavroula, Do Ron, Jun Goo, Hu Youna, Kang Hyun Min, Xue Chenyi, Goel Anuj, Farrall Martin, Duga Stefano, Merlini Pier Angelica, Asselta Rosanna, Girelli Domenico, Olivieri Oliviero, Martinelli Nicola, Yin Wu, Reilly Dermot, Speliotes Elizabeth, Fox Caroline S, Hveem Kristian, Holmen Oddgeir L, Nikpay Majid, Farlow Deborah N, Assimes Themistocles L, Franceschini Nora, Robinson Jennifer, North Kari E, Martin Lisa W, DePristo Mark, Gupta Namrata, Escher Stefan A, Jansson Jan-Håkan, Van Zuydam Natalie, Palmer Colin N A, Wareham Nicholas, Koch Werner, Meitinger Thomas, Peters Annette, Lieb Wolfgang, Erbel Raimund, Konig Inke R, Kruppa Jochen, Degenhardt Franziska, Gottesman Omri, Bottinger Erwin P, O'Donnell Christopher J, Psaty Bruce M, Ballantyne Christie M, Abecasis Goncalo, Ordovas Jose M, Melander Olle, Watkins Hugh, Orho-Melander Marju, Ardissino Diego, Loos Ruth J F, McPherson Ruth, Willer Cristen J, Erdmann Jeanette, Hall Alistair S, Samani Nilesh J, Deloukas Panos, Schunkert Heribert, Wilson James G, Kooperberg Charles, Rich Stephen S, Tracy Russell P, Lin Dan-Yu, Altshuler David, Gabriel Stacey, Nickerson Deborah A, Jarvik Gail P, Cupples L Adrienne, Reiner Alex P, Boerwinkle Eric, Kathiresan Sekar
Abstract excerpt
BACKGROUND: Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the human genome (the exome) has the potential to identify rare mutations that have a large effect on phenotype. METHODS: We sequenced the protein-coding regions of 18,666 genes in each of 3734 participants of European or African ancestry in the Exome...
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