The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.

doi:10.1097/CEJ.0000000000000240

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Mar 2017

Neidhardt Guido, Becker Alexandra, Hauke Jan, Horváth Judit, Bogdanova Markov Nadja, Heilmann-Heimbach Stefanie, Hellebrand Heide, Thiele Holger, Altmüller Janine, Nürnberg Peter, Meindl Alfons, Rhiem Kerstin, Blümcke Britta, Wappenschmidt Barbara, Schmutzler Rita K, Hahnen Eric

Abstract excerpt

Whereas RAD51C mutations increase the relative risk for ovarian cancer (OC) to 5.88 (95% confidence interval=2.91-11.88, P=7.65×10), the associated risks for breast cancer (BC) remain largely unknown, as deleterious RAD51C alterations are extremely rare in BC-only families. Here, we report the results of a RAD51C mutational screening in a large series of German familial index patients negative for pathogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Exons

Share to BRCA1 gene

Share to Genetic Predisposition to Disease

Share to Mutation

Share to Ovarian Neoplasms

Share to Pedigree

Source

Open in PubMed

Identifiers

PMID: 27622768
DOI: 10.1097/CEJ.0000000000000240

Genes

BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer.PMID 27622768Read ↗

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.Semantic proximity Read ↗

The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique PopulationSemantic proximity Read ↗

Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.Semantic proximity Read ↗

About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants.Semantic proximity Read ↗

Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.Semantic proximity Read ↗

Germline RAD51C mutations in ovarian cancer susceptibility.Semantic proximity Read ↗

RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.Semantic proximity Read ↗

RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.Semantic proximity Read ↗

A decade of RAD51C and RAD51D germline variants in cancer.Semantic proximity Read ↗

RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.Semantic proximity Read ↗

A dominant RAD51C pathogenic splicing variant predisposes to breast and ovarian cancer in the Newfoundland population due to founder effect.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.