Article
Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications.
Endocrine-related cancer - 1 Sept 2009
Jaffrain-Rea Marie-Lise, Angelini Mariolina, Gargano Donatella, Tichomirowa Maria A, Daly Adrian F, Vanbellinghen Jean-François, D'Innocenzo Emanuela, Barlier Anne, Giangaspero Felice, Esposito Vincenzo, Ventura Luca, Arcella Antonietta, Theodoropoulou Marily, Naves Luciana A, Fajardo Carmen, Zacharieva Sabina, Rohmer Vincent, Brue Thierry, Gulino Alberto, Cantore Giampaolo, Alesse Edoardo, Beckers Albert
Abstract excerpt
Germline mutations of the aryl hydrocarbon receptor (AHR)-interacting protein (AIP) gene confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated PA. To provide further insights into the possible role of AIP in pituitary tumour pathogenesis, the expression of AIP and AHR was determined by real-time RT-PCR and/or immunohistochemistry (IHC) in a large series of PA (n=103),...
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