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Article

Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors.

Development (Cambridge, England) - 15 Oct 2016

Shin Masahiro, Male Ira, Beane Timothy J, Villefranc Jacques A, Kok Fatma O, Zhu Lihua J, Lawson Nathan D

Abstract excerpt

Vascular endothelial growth factor C (Vegfc) activates its receptor, Flt4, to induce lymphatic development. However, the signals that act downstream of Flt4 in this context in vivo remain unclear. To understand Flt4 signaling better, we generated zebrafish bearing a deletion in the Flt4 cytoplasmic domain that eliminates tyrosines Y1226 and 1227. Embryos bearing this deletion failed to initiate sprouting or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27621059
DOI: 10.1242/dev.137901
PMCID: PMC5087638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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