Article
Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3.
Nature communications - 16 Jul 2024
Chen Jingying, Ding Jing, Li Yongyu, Feng Fujuan, Xu Yuhang, Wang Tao, He Jianbo, Cang Jing, Luo Lingfei
Abstract excerpt
In zebrafish, brain lymphatic endothelial cells (BLECs) are essential for meningeal angiogenesis and cerebrovascular regeneration. Although epidermal growth factor-like domain 7 (Egfl7) has been reported to act as a pro-angiogenic factor, its roles in lymphangiogenesis remain unclear. Here, we show that Egfl7 is expressed in both blood and lymphatic endothelial cells. We generate an egfl7 cq180 mutant with a...
Topics
Join the communities discussing this publication.