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Article

CD 274 ( PDL 1) and JAK 2 genomic amplifications in pulmonary squamous‐cell and adenocarcinoma patients

10 Aug 2017

Abstract excerpt

AIMS: CD274 (PDL1) and JAK2 (9p24.1) gene amplifications have been recently described in pulmonary carcinomas in association with programmed death-ligand 1 (PD-L1) expression. Furthermore, PTEN loss has been explored preclinically in relation to PD-L1 expression. Our aim was to determine whether these genomic alterations affect PD-L1 expression levels in non-small-cell lung cancer. METHODS AND RESULTS: PD-L1 and...

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PMID: 28795418
DOI: 10.1111/his.13339

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