Article
A calcium sensor in the sodium channel modulates cardiac excitability.
Nature - 24 Jan 2002
Tan Hanno L, Kupershmidt Sabina, Zhang Rong, Stepanovic Svetlana, Roden Dan M, Wilde Arthur A M, Anderson Mark E, Balser Jeffrey R
Abstract excerpt
Sodium channels are principal molecular determinants responsible for myocardial conduction and maintenance of the cardiac rhythm. Calcium ions (Ca2+) have a fundamental role in the coupling of cardiac myocyte excitation and contraction, yet mechanisms whereby intracellular Ca2+ may directly modulate Na channel function have yet to be identified. Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.