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Article

NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer.

Oncotarget - 6 Sept 2016

Wu Nan, Jia Deshui, Ibrahim Ali H, Bachurski Cindy J, Gronostajski Richard M, MacPherson David

Abstract excerpt

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor type that is typically metastatic upon diagnosis. We have a poor understanding of the factors that control SCLC progression and metastasis. TheNFIB transcription factor is frequently amplified in mouse models of SCLC, but clear evidence that NFIB promotes SCLC in vivo is lacking. We report that in mouse models, Nfib amplifications are far...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27613844
DOI: 10.18632/oncotarget.11583
PMCID: PMC5295369

Genes

NFIB

Provenance

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