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Article

The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer.

Respiratory research - 21 Mar 2026

Lu Mingjun, Zhu Xiaoyue, Wang Chenyang, Hou Jiabao, Guo Jingwei, Zhao Jiaqi, Qin Zhendong, Wu Jinghong, Cao Xiaoqing, Zhang Tongmei, Wang Dongchang, Ma Teng

Abstract excerpt

BACKGROUND: Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid progression and poor prognosis. This study integrates bioinformatics with experimental validation to characterize the role of Frizzled-3 (FZD3), a Wnt receptor, in SCLC progression. METHODS: We analyzed transcriptomic data from 102 SCLC and 55 normal lung tissues retrieved from the Gene Expression Omnibus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41862898
DOI: 10.1186/s12931-026-03634-1
PMCID: PMC13126896

Genes

FZD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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