NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer

Abstract excerpt

Small cell lung cancer (SCLC) is an aggressive type of lung cancer driven by combined loss of the tumor suppressors RB1 and TP53. SCLC is highly metastatic and despite good initial response to chemotherapy patients usually relapse, resulting in poor survival. Therefore, better understanding of the mechanisms driving SCLC pathogenesis is required to identify new therapeutic targets. Here we identified a critical...

Topics

Join the communities discussing this publication.

• Cancer Mechanisms and Therapy
• Lung Cancer Research Studies
• NF-κB Signaling Pathways