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Lineage-committed osteoclast precursors circulate in blood and settle down into bone

23 Aug 2011

Abstract excerpt

Osteoclasts are derived from the monocyte/macrophage lineage, but little is known about osteoclast precursors in circulation. We previously showed that cell cycle-arrested quiescent osteoclast precursors (QOPs) were detected along bone surfaces as direct osteoclast precursors. Here we show that receptor activator of NF-κB (RANK)-positive cells isolated from bone marrow and peripheral blood possess characteristics...

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PMID: 21898588
DOI: 10.1002/jbmr.490

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