Article
Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa.
Scientific reports - 9 Sept 2016
Okada Chiaki, Wakabayashi Hiroko, Kobayashi Momoko, Shinoda Akira, Tanaka Isao, Yao Min
Abstract excerpt
Lipid A (also known as endotoxin) is the hydrophobic portion of lipopolysaccharides. It is an essential membrane component required for the viability of gram-negative bacteria. The enzymes involved in its biosynthesis are attractive targets for the development of novel antibiotics. LpxH catalyzes the fourth step of the lipid A biosynthesis pathway and cleaves the pyrophosphate bond of UDP-2,3-diacylglucosamine to...
Topics
- Bacterial Proteins
- Catalytic Domain
- Crystallography, X-Ray
- Glycolipids
- Hydrophobic and Hydrophilic Interactions
- Lipid A
- Models, Molecular
- Mutation
- Protein Binding
- Protein Conformation
- Pseudomonas aeruginosa