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Article

Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa.

Scientific reports - 9 Sept 2016

Okada Chiaki, Wakabayashi Hiroko, Kobayashi Momoko, Shinoda Akira, Tanaka Isao, Yao Min

Abstract excerpt

Lipid A (also known as endotoxin) is the hydrophobic portion of lipopolysaccharides. It is an essential membrane component required for the viability of gram-negative bacteria. The enzymes involved in its biosynthesis are attractive targets for the development of novel antibiotics. LpxH catalyzes the fourth step of the lipid A biosynthesis pathway and cleaves the pyrophosphate bond of UDP-2,3-diacylglucosamine to...

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Identifiers

PMID: 27609419
DOI: 10.1038/srep32822
PMCID: PMC5016852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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