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Article

Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites.

Scientific reports - 9 Jul 2020

Scala Romina, Di Matteo Adele, Coluccia Antonio, Lo Sciuto Alessandra, Federici Luca, Travaglini-Allocatelli Carlo, Visca Paolo, Silvestri Romano, Imperi Francesco

Abstract excerpt

Lipopolysaccharide (LPS) is a critical component of the outer membrane (OM) of many Gram-negative bacteria. LPS is translocated to the OM by the LPS transport (Lpt) system. In the human pathogen Pseudomonas aeruginosa, the periplasmic Lpt component, LptH, is essential for LPS transport, planktonic and biofilm growth, OM stability and infectivity. LptH has been proposed to oligomerize and form a protein bridge...

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PMID: 32647254
DOI: 10.1038/s41598-020-68054-7
PMCID: PMC7347655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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