Article
Influence of HLA class I, HLA class II and KIRs on vertical transmission and chronicity of hepatitis C virus in children.
PloS one - 1 Jan 2017
Ruiz-Extremera A, Pavón-Castillero E J, Florido M, Muñoz de Rueda P, Muñoz-Gámez J A, Casado J, Carazo A, Quiles R, Jiménez-Ruiz S M, Gila A, Luna J D, León J, Salmerón J
Abstract excerpt
BACKGROUND & AIM: There is evidence that maternal viral load of HCV during delivery influences the risk for Mother-to-child transmission (MTCT), but this does not explain all cases. We study the role of the immunogenetic profile (HLA, KIRs and KIR-ligand binding) of mothers and children in HCV-MTCT and in chronicity in the children. METHODOLOGY: 79 HCV-RNA (+) mothers and their 98 children were included. 24...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.