Article
Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses.
Nature medicine - 1 Nov 2013
Honegger Jonathan R, Kim Seungtaek, Price Aryn A, Kohout Jennifer A, McKnight Kevin L, Prasad Mona R, Lemon Stanley M, Grakoui Arash, Walker Christopher M
Abstract excerpt
Globally, about 1% of pregnant women are persistently infected with the hepatitis C virus (HCV). Mother-to-child transmission of HCV occurs in 3-5% of pregnancies and accounts for most new childhood infections. HCV-specific CD8(+) cytotoxic T lymphocytes (CTLs) are vital in the clearance of acute HCV infections, but in the 60-80% of infections that persist, these cells become functionally exhausted or select for...
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