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Monitoring KRAS mutations in circulating DNA and tumor cells using digital droplet PCR during treatment of KRAS-mutated lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2016

Guibert Nicolas, Pradines Anne, Farella Magali, Casanova Anne, Gouin Sandrine, Keller Laura, Favre Gilles, Mazieres Julien

Abstract excerpt

Liquid biopsies are a new non-invasive strategy to detect and monitor the biology of non-small-cell lung cancer (NSCLC) in the era of personalized medicine. KRAS is an oncogenic driver that is mutated in 30% of NSCLCs and is associated with a poor prognosis. 62 samples from 32 patients, treated for metastatic KRAS-mutated lung adenocarcinoma, had DNA extracted from plasma and circulating tumor cells (CTCs)...

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Source

Identifiers

PMID: 27597273
DOI: 10.1016/j.lungcan.2016.07.021

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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