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Article

CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

Nature - 15 Apr 2010

Thomson John P, Skene Peter J, Selfridge Jim, Clouaire Thomas, Guy Jacky, Webb Shaun, Kerr Alastair R W, Deaton Aimée, Andrews Rob, James Keith D, Turner Daniel J, Illingworth Robert, Bird Adrian

Abstract excerpt

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base composition and high density of CpG dinucleotides. Most human gene promoters are embedded within CGIs that lack DNA methylation and coincide with sites of histone H3 lysine 4 trimethylation (H3K4me3), irrespective of transcriptional activity. In spite of these intriguing correlations, the functional significance of non-methylated...

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Identifiers

PMID: 20393567
DOI: 10.1038/nature08924
PMCID: PMC3730110

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