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New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints

2 Jul 2016

Abstract excerpt

Esophageal cancer remains a highly lethal malignancy in which relatively modest therapeutic advances have been made over the past several decades. Cytotoxic therapy remains the mainstay of treatment for both advanced esophageal adenocarcinoma and squamous cell carcinoma (SCC), with incremental benefit conferred by antibodies targeting HER2 and VEGFR in selected patients. However, intrinsic or acquired resistance...

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PMID: 27370606
DOI: 10.1158/1078-0432.ccr-16-0292

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