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Article

Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression.

Experimental eye research - 1 Oct 2016

Peng Shaomin, Wang Shao-Bin, Singh Deepti, Zhao Peter Y C, Davis Katherine, Chen Bo, Adelman Ron A, Rizzolo Lawrence J

Abstract excerpt

Mutations of claudin-19 cause severe ocular deficits that are not easily reconciled with its role in regulating the outer blood retinal barrier. ARPE-19 is a widely used culture model of the retinal pigment epithelium (RPE). ARPE-19 is unique among epithelial cell lines, because it expresses all tight junction proteins except claudin family members. ARPE-19 also loses aspects of the RPE phenotype with cell...

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Source

Identifiers

PMID: 27593915
DOI: 10.1016/j.exer.2016.08.021

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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