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Article

Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19.

Investigative ophthalmology & visual science - 9 Sept 2011

Ahmado Ahmad, Carr Amanda-Jayne, Vugler Anthony A, Semo Ma'ayan, Gias Carlos, Lawrence Jean M, Chen Li Li, Chen Fred K, Turowski Patric, da Cruz Lyndon, Coffey Peter J

Abstract excerpt

PURPOSE: Cultured retinal pigment epithelium (RPE) may become a therapeutic option for transplantation in retinal disease. However maintaining a native RPE phenotype in vitro has proven challenging. The human RPE cell-line ARPE-19 is used widely as an alternative to primary RPE. It is grown in DMEM/F12 medium as standard, but its phenotype is dependent on culture conditions, and many differentiation markers are...

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Identifiers

PMID: 21743014
DOI: 10.1167/iovs.10-6374

Genes

RPE
RPE65

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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