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Article

Evidence for a Common Evolutionary Origin of Coronavirus Spike Protein Receptor-Binding Subunits

29 Dec 2011

Abstract excerpt

Among different coronavirus genera, the receptor-binding S1 subunits of their spike proteins differ in primary, secondary, and tertiary structures. This study identified shared structural topologies (connectivity of secondary structural elements) in S1 domains of different coronavirus genera. The results suggest that coronavirus S1 subunits share a common evolutionary origin but have attained diverse sequences...

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PMID: 22205743
DOI: 10.1128/jvi.06882-11

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