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Article

Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells

24 Jul 2020

Abstract excerpt

Embryonic stem cells can propagate indefinitely in a pluripotent state, able to differentiate into all types of specialized cells when restored to the embryo. What sustains their pluripotency during propagation remains unclear. Here, we show that core pluripotency factors OCT4 and SOX2 suppress chaperone-mediated autophagy (CMA), a selective form of autophagy, until the initiation of differentiation. Low CMA...

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PMID: 32703873
DOI: 10.1126/science.abb4467

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