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Article

Nuclear import of human histone lysine-specific demethylase LSD1.

Journal of biochemistry - 1 Dec 2014

Jin Yanhua, Kim Tae Young, Kim Min Seong, Kim Min Aeh, Park Su Hyung, Jang Yeun Kyu

Abstract excerpt

Upregulation and nuclear retention of the human histone demethylase LSD1 are correlated with aggressiveness and poor outcome of several cancer types, but the molecular mechanism of LSD1 nuclear import remains unclear. Here, we found that the N-terminal flexible region of LSD1 contains a nuclear localization signal (NLS), (112)RRKRAK(117). Mutation or deletion of the NLS completely abolished the nuclear import of...

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Identifiers

PMID: 24986870
DOI: 10.1093/jb/mvu042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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