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Article

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance

15 Feb 2016

Abstract excerpt

BACKGROUND: SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and glioma treatment remain unclear. METHODS: SOX2 and SOX9 levels were examined in human biopsies. Gain and loss of function determined the impact of altering SOX2 and SOX9 on cell proliferation, senescence, stem cell activity, tumorigenesis and...

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PMID: 26878385
DOI: 10.1517/14728222.2016.1151002

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