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Article

Effect in virulence of switching conserved homologous capsular polysaccharide genes from Klebsiella pneumoniae serotype K1 into K20.

Virulence - 4 Jul 2017

Lin Chii-Lan, Chen Fei-Hsu, Huang Li-Yueh, Chang Jen-Chang, Chen Jiun-Han, Tsai Yu-Kuo, Chang Feng-Yee, Lin Jung-Chung, Siu L Kristopher

Abstract excerpt

The capsular polysaccharides in different serotypes of Klebsiella pneumoniae (KP) coded by the (CPS) gene cluster are characterized by a conserved and a hyper-variable region. We performed a virulence study by switching genes in the highly conserved region of the CPS cluster between strains. Six genes in the CPS conserved region in serotype K20, including galF, acidPPc, wzi, wza, wzb and wzc, were knocked out and...

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Identifiers

PMID: 27565716
DOI: 10.1080/21505594.2016.1228508
PMCID: PMC5538342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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