Article
Collapsed methylation quantitative trait loci analysis for low frequency and rare variants.
Human molecular genetics - 1 Oct 2016
Richardson Tom G, Shihab Hashem A, Hemani Gibran, Zheng Jie, Hannon Eilis, Mill Jonathan, Carnero-Montoro Elena, Bell Jordana T, Lyttleton Oliver, McArdle Wendy L, Ring Susan M, Rodriguez Santiago, Campbell Colin, Smith George Davey, Relton Caroline L, Timpson Nicholas J, Gaunt Tom R
Abstract excerpt
BACKGROUND: Single variant approaches have been successful in identifying DNA methylation quantitative trait loci (mQTL), although as with complex traits they lack the statistical power to identify the effects from rare genetic variants. We have undertaken extensive analyses to identify regions of low frequency and rare variants that are associated with DNA methylation levels. METHODS: We used repeated...
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