Improving alignment accuracy on homopolymer regions for semiconductor-based sequencing technologies.

Abstract excerpt

BACKGROUND: Ion Torrent and Ion Proton are semiconductor-based sequencing technologies that feature rapid sequencing speed and low upfront and operating costs, thanks to the avoidance of modified nucleotides and optical measurements. Despite of these advantages, however, Ion semiconductor sequencing technologies suffer much reduced sequencing accuracy at the genomic loci with homopolymer repeats of the same...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bayes Theorem
• Share to Genetic Variation
• Share to Genome
• Share to High-Throughput Nucleotide Sequencing