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Article

Improving indel detection specificity of the Ion Torrent PGM benchtop sequencer.

PloS one - 1 Jan 2012

Yeo Zhen Xuan, Chan Maurice, Yap Yoon Sim, Ang Peter, Rozen Steve, Lee Ann Siew Gek

Abstract excerpt

The emergence of benchtop sequencers has made clinical genetic testing using next-generation sequencing more feasible. Ion Torrent's PGM™ is one such benchtop sequencer that shows clinical promise in detecting single nucleotide variations (SNVs) and microindel variations (indels). However, the large number of false positive indels caused by the high frequency of homopolymer sequencing errors has impeded PGM™'s...

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Identifiers

PMID: 23029247
DOI: 10.1371/journal.pone.0045798
PMCID: PMC3446914

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BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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