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Article

A simple method using PyrosequencingTM to identify de novo SNPs in pooled DNA samples.

Nucleic acids research - 1 Mar 2011

Lin Yeong-Shin, Liu Fu-Guo Robert, Wang Tzi-Yuan, Pan Cheng-Tsung, Chang Wei-Ting, Li Wen-Hsiung

Abstract excerpt

A practical way to reduce the cost of surveying single-nucleotide polymorphism (SNP) in a large number of individuals is to measure the allele frequencies in pooled DNA samples. Pyrosequencing(TM) has been frequently used for this application because signals generated by this approach are proportional to the amount of DNA templates. The Pyrosequencing(TM) pyrogram is determined by the dispensing order of dNTPs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21131285
DOI: 10.1093/nar/gkq1249
PMCID: PMC3061071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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