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Cellular Phenotypic Analysis of Macrophage Activation Unveils Kinetic Responses of Agents Targeting Phosphorylation.

SLAS discovery : advancing life sciences R & D - 1 Jan 2017

Cao Qian, Yao Junlin, Li Heyuan, Tao Bo, Cai Yibo, Xiao Peng, Cheng Hongqiang, Ke Yuehai

Abstract excerpt

Macrophages are highly plastic cells, which serve as sentinels of the host immune system due to their ability to recognize and respond to microbial products rapidly and dynamically. Appropriate regulation of macrophage activation is essential for pathogen clearance or preventing autoimmune diseases. However, regularly used endpoint assays for analyzing macrophage functions have the limitations of being static and...

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PMID: 27554457
DOI: 10.1177/1087057116663166

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