Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α1,3-Galactosyltransferase Gene-Knockout Pigs for Xenotransplantation: Where Do We Go From Here?

9 Jul 2007

Abstract excerpt

The ability to genetically engineer pigs that no longer express the Galalpha1,3Gal (Gal) oligosaccharide has been a significant step toward the clinical applicability of xenotransplantation. Using a chronic immunosuppressive regimen based on costimulatory blockade, hearts from these pigs have survived from 2 to 6 months in baboons. Graft failure was predominantly from the development of a thrombotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Genetics and Reproduction
Share to Virus-based gene therapy research
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17627227
DOI: 10.1097/01.tp.0000260427.75804.f2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α1,3-Galactosyltransferase Gene-Knockout Pigs for Xenotransplantation: Where Do We Go From Here?PMID 17627227Read ↗

Genetic modification of pigs as organ donors for xenotransplantationSemantic proximity Read ↗

Progress in xenotransplantation following the introduction of gene-knockout technologySemantic proximity Read ↗

Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: The first clinical stepsSemantic proximity Read ↗

Perspectives on the Optimal Genetically Engineered Pig in 2018 for Initial Clinical Trials of Kidney or Heart XenotransplantationSemantic proximity Read ↗

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantationSemantic proximity Read ↗

Controlling coagulation dysregulation in xenotransplantationSemantic proximity Read ↗

A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation modelSemantic proximity Read ↗

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantationSemantic proximity Read ↗

Comparison of hematologic, biochemical, and coagulation parameters in α1,3‐galactosyltransferase gene‐knockout pigs, wild‐type pigs, and four primate speciesSemantic proximity Read ↗

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native PigsSemantic proximity Read ↗

Pigs in Transplantation Research and Their Potential as Sources of Organs in Clinical XenotransplantationSemantic proximity Read ↗

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pigSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.