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MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling

1 Jan 2016

Abstract excerpt

Liver fibrosis is a repair process in response to damage in the liver; however, severe and chronic injury promotes the accumulation of fibrous matrix, destroying the normal functions and architecture of liver. Hepatic stellate cells (HSCs) are quiescent in normal livers, but in damaged livers, they transdifferentiate into myofibroblastic HSCs, which produce extracellular matrix proteins. Hedgehog (Hh) signaling...

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PMID: 27547008
DOI: 10.3748/wjg.v22.i29.6652

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