Article
Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: First Case from the National Iranian Registry and Review of the Literature.
Immunological investigations - 1 Feb 2022
Sharifinejad Niusha, Azizi Gholamreza, Behniafard Nasrin, Zaki-Dizaji Majid, Jamee Mahnaz, Yazdani Reza, Abolhassani Hassan, Aghamohammadi Asghar
Abstract excerpt
BACKGROUND: Protein kinase C is a family of serine/threonine kinases that play a key role in the adaptive immune cell signaling, as well as regulation of growth, apoptosis, and differentiation of a variety of cell types. Patients homozygous for a null mutation of the Protein Kinase C Delta (PRKCD) gene, present clinical feature of immune dysregulation with susceptibility to Epstein-Barr virus infection. However,...
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