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A <i>Pseudomonas aeruginosa</i> hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils

18 Aug 2016

Abstract excerpt

Pseudomonas aeruginosa (PA) infection in cystic fibrosis (CF) lung disease causes airway neutrophilia and hyperinflammation without effective bacterial clearance. We evaluated the immunostimulatory activities of lipid A, the membrane anchor of LPS, isolated from mutants of PA that synthesize structural variants, present in the airways of patients with CF, to determine if they correlate with disease severity and...

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Share to Bacterial biofilms and quorum sensing
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PMID: 27538572
DOI: 10.1189/jlb.4vma0316-101r

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