Article
A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.
Investigative ophthalmology & visual science - 1 Aug 2016
Liu Yutao, Bailey Jessica Cooke, Helwa Inas, Dismuke W Michael, Cai Jingwen, Drewry Michelle, Brilliant Murray H, Budenz Donald L, Christen William G, Chasman Daniel I, Fingert John H, Gaasterland Douglas, Gaasterland Terry, Gordon Mae O, Igo Robert P, Kang Jae H, Kass Michael A, Kraft Peter, Lee Richard K, Lichter Paul, Moroi Sayoko E, Realini Anthony, Richards Julia E, Ritch Robert, Schuman Joel S, Scott William K, Singh Kuldev, Sit Arthur J, Song Yeunjoo E, Vollrath Douglas, Weinreb Robert, Medeiros Felipe, Wollstein Gadi, Zack Donald J, Zhang Kang, Pericak-Vance Margaret A, Gonzalez Pedro, Stamer W Daniel, Kuchtey John, Kuchtey Rachel W, Allingham R Rand, Hauser Michael A, Pasquale Louis R, Haines Jonathan L, Wiggs Janey L
Abstract excerpt
PURPOSE: Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated with primary open-angle glaucoma (POAG). METHODS: Using the NEIGHBORHOOD data set (3853 cases/33,480 controls with European ancestry), we first assessed the relation between 85 variants in 76 MIR genes and overall POAG. Subtype-specific analyses...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.