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Article

Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-Analysis.

JAMA ophthalmology - 1 May 2024

Liang Yu Jing, Wang Yu Yao, Rong Shi Song, Chen Zhen Ji, Chen Shu Ying, Tham Jenson A, Chan Poemen P, Yam Jason C, Wiggs Janey L, Pang Chi Pui, Tham Clement C, Chen Li Jia

Abstract excerpt

Importance: Effects of genetic variants on primary angle-closure disease remained uncertain. Objective: To systematically review the associations of common single-nucleotide variants (SNVs) and rare coding variants with primary angle-closure disease, its subtypes (including primary angle-closure glaucoma, primary angle-closure suspect, and primary angle-closure) and progression. Data Sources: Eligible studies...

Topics

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FBN1 gene
LOXL1 gene
MMP9 gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glaucoma, Angle-Closure

Intraocular Pressure

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 38546604
DOI: 10.1001/jamaophthalmol.2024.0363
PMCID: PMC10979365

Genes

ABCA1
ATOH7
CALCRL
COL11A1
FBN1
IL6
LOXL1
MMP19
MMP9
PCMTD1
ST18
VAV3
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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