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Article

Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations.

Cancer research - 15 Oct 2016

Fu Yu, Jovelet Cécile, Filleron Thomas, Pedrero Marion, Motté Nelly, Boursin Yannick, Luo Yufei, Massard Christophe, Campone Mario, Levy Christelle, Diéras Véronique, Bachelot Thomas, Garrabey Julie, Soria Jean-Charles, Lacroix Ludovic, André Fabrice, Lefebvre Celine

Abstract excerpt

DNA extracted from cancer patients' whole blood may contain somatic mutations from circulating tumor DNA (ctDNA) fragments. In this study, we introduce cmDetect, a computational method for the systematic identification of ctDNA mutations using whole-exome sequencing of a cohort of tumor and corresponding peripheral whole-blood samples. Through the analysis of simulated data, we demonstrated an increase in...

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Identifiers

PMID: 27535334
DOI: 10.1158/0008-5472.CAN-15-3457

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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