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Article

Dual R108K and G189D Mutations in the NS1 Protein of A/H1N1 Influenza Virus Counteract Host Innate Immune Responses.

Viruses - 13 May 2021

Huang Meng-Ting, Zhang Sen, Wu Ya-Nan, Li Wei, Li Yu-Chang, Zhou Chang-Shuai, Kang Xiao-Ping, Jiang Tao

Abstract excerpt

Influenza A viruses (IAV) modulate host antiviral responses to promote growth and pathogenicity. Here, we examined the multifunctional IAV nonstructural protein 1 (NS1) of influenza A virus to better understand factors that contribute to viral replication efficiency or pathogenicity. In 2009, a pandemic H1N1 IAV (A/California/07/2009 pH1N1) emerged in the human population from swine. Seasonal variants of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34068322
DOI: 10.3390/v13050905
PMCID: PMC8153306

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