Associations between MDR1 C3435T polymorphism and drug-resistant epilepsy in the Polish population.

doi:10.1007/s13760-016-0690-6

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Article

Associations between MDR1 C3435T polymorphism and drug-resistant epilepsy in the Polish population.

Acta neurologica Belgica - 1 Mar 2017

Skalski Dominik, Wendorff Janusz, Romanowicz Hanna, Rysz Andrzej, Marchel Andrzej, Stasiołek Mariusz, Smolarz Beata

Abstract excerpt

Epilepsy is a common neurological disorder. About one-third of epileptic patients demonstrate multidrug resistance (MDR) phenotype and develop drug-resistant epilepsy (DRE). Single nucleotide polymorphism (SNP) C3435T (rs1045642), identified in the MDR1 gene, is associated with an increased intestinal expression of P-glycoprotein (P-gp) which affects the levels of anti-epileptic drugs in plasma. The reported...

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PMID: 27534401
DOI: 10.1007/s13760-016-0690-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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