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Article

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

17 Aug 2016

Abstract excerpt

Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo. However, in two-dimensional cultures, primary human hepatocytes (PHHs) rapidly dedifferentiate, resulting in loss of hepatic functions that significantly limits their usefulness as an in vitro model of liver biology, liver diseases, as well as drug metabolism and...

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PMID: 27532775
DOI: 10.1002/hep.28780

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