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Article

RBM20 Regulates Circular RNA Production From the Titin Gene

17 Aug 2016

Abstract excerpt

RATIONALE: RNA-binding motif protein 20 (RBM20) is essential for normal splicing of many cardiac genes, and loss of RBM20 causes dilated cardiomyopathy. Given its role in splicing, we hypothesized an important role for RBM20 in forming circular RNAs (circRNAs), a novel class of noncoding RNA molecules. OBJECTIVE: To establish the role of RBM20 in the formation of circRNAs in the heart. METHODS AND RESULTS: Here,...

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Identifiers

PMID: 27531932
DOI: 10.1161/circresaha.116.309568

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